 Molecular Biology in Medicinal Chemistry
ISBN: 978-3-527-30431-8
Hardcover
435 pages
April 2004
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Foreword.
Contributors.
PART I: MOLECULAR TARGETS.
1. Cellular Assays in Drug Discovery (H. Albrecht, et al.).
2. Gene Knockout Models (P. Ruth & M. Sausbier).
3. Reporter Gene Assay Systems for the Investigation of G-protein-coupled Receptors (M. Dinger & A. Beck-Sickinger).
4. From the Human Genome to New Drugs: The Potential of Orphan G-protein-coupled Receptors (R. Bakker & R. Leurs).
PART II: SYNTHESIS.
5. Stereoselective Synthesis with the Help of Recombinant Enzymes (N. Rao & A. Liese).
6. Nucleic Acid Drugs (J. Engels & J. Parsch).
PART III: ANALYSIS.
7. Recent Trends in Enantioseparation of Chiral Drugs (B. Chankvetadze).
8. Affinity Chromatography (G. Scriba).
9. Nuclear Magnetic Resonance-based Drug Discovery (U. Günther, et al.).
10.13C- and 15N-Isotopic Labeling of Proteins (C. Klammt, et al.).
11. Application of Antibody Fragments as Crystallization Enhancers (C. Hunte & C. Münke).
PART IV: KINETICS, METABOLISM AND TOXICOLOGY.
12. Pharmacogenetics: The Effect of Inherited Genetic Variation on Drug Disposition and Drug Response (K. Kesseler).
13. Pharmacogenomics of Bioavaliability and Elimination (I Cascorbi & H. Kroemer).
14. Toxicogenomics: Integration of New Molecular Biological Tools in Toxicology (W. Heijne, et al.).
Index.
