Editors: Derek J. Cahdwick (Organizer) and Jamie Goode.

This Symposim was based on a proposal made by Mitchell Fink and Mervyn Singer.

Chair’s introduction (Mitchell P. Fink).

Discussion.

Strategies to modulate cellular energetic metabolism during sepsis (Alessandro Protti and Mervyn Singer).

Discussion.

Immunostimulation is a rational therapeutic strategy in sepsis (Jérôme Pugin).

Discussion.

Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis (Alfred Ayala, Doreen E. Wesche-Soldato, Mario Perl, Joanne L. Lomas-Neira, Ryan Swan and Chun-Shiang Chung).

Discussion.

Modulating neutrophil apoptosis (John C. Marshall, Zeenat Malam and Songhui Jia).

Discussion.

HMGB1 as a potential therapeutic target(Haichao Wang, Wei Li, Richard Goldstein, Kevin J. Traceyand Andrew E. Sama).

Discussion.

Poly (ADP-ribose) polymerase activation and circulatory shock (Csaba Szabó).

Discussion.

Choosing the right substrate (Xavier Leverve, Cécile Batandier and Eric Fontaine).

Discussion.

Inhibiting glycogen synthase kinase 3β in sepsis (Laura Dugo, Marika Collin, David A. Allen, Nimesh S.A. Patel, Inge Bauer, Eero M. A. Mervaala, Marjut Louhelainen, Simon J. Foster, Muhammad M. Yaqoob and Christoph Thiemermann).

Discussion.

Ethyl pyruvate: a novel treatment for sepsis (Mitchell P. Fink).

Discussion.

General discussion I.

Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models(Stefan W. Ryter and Augustine M. K. Choi).

Discussion.

The hypothalamic pituitary adrenal axis in sepsis (Andrea Polito, Jérôme Aboab andDjillali Annane).

Discussion.

Modulating the endocrine response in sepsis: insulin and blood glucose control (Ilse Vanhorebeek, Lies Langouche and Greet Van den Berghe).

Discussion.

The neuronal strategy for inflammation(Luis Ulloaand Ping Wang).

Discussion.

Beta-blockade in burns (C. T. Pereira, M. G. Jeschke and D. N. Herndon).

Discussion.

System interactions (Mervyn Singer).

Discussion.

Protecting the permeability pore and mitochondrial biogenesis (C. A. Piantadosi, M. S. Carraway, D. W. Haden and H. B. Suliman).

Discussion.

Contributor Index.

Subject index.